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https://doi.org/10.1016/j.tet.2015.03.023
Copy DOIJournal: Tetrahedron | Publication Date: Mar 11, 2015 |
Citations: 14 |
Arylnaphthalene lactones, which are natural lignans and isolated from a wide range of plants, exhibit significant biological activity, including anticancer and antiviral activities. In this work, we have developed a versatile and convergent synthetic method for arylnaphthalene lactones, which involves the use of benzoin condensation and thermal intramolecular cyclization for preparing the key intermediate, naphthol. A high-yielding Suzuki reaction is utilized to introduce the aryl group to the C9 position of the naphthalene lactones, which allows for the construction of the arylnaphthalene lactone skeleton.
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