Abstract
In the present study, sponges with the antibiotic tetracycline hydrochloride (TCH) loaded into alginate incorporated with gelatin (G/SA) were fabricated. The G/SA sponges were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and thermogravimetric (TG) analysis. G/SA sponges show a three-dimensional network structure with high porosity. An excellent swelling behavior and a controlled TCH release performance are observed from G/SA sponges. Moreover, they exhibit good antibacterial activity against both Gram-positive and Gram-negative bacteria.
Highlights
As the largest organ, the skin acts as a barrier against the invasion of the human body by pathogens [1]
Alginate, cellulose, collagen, hyaluronic acid and gelatin in the form of films, sponges and fibers have been applied in wound dressing applications [6,7,8]
The exudate absorption capacity is directly affected by the surface morphology and porosity of
Summary
The skin acts as a barrier against the invasion of the human body by pathogens [1]. Alginate, cellulose, collagen, hyaluronic acid and gelatin in the form of films, sponges and fibers have been applied in wound dressing applications [6,7,8]. Gelatin is a water-soluble denatured protein derived from skin, tendons or bones [13] It possesses many advantages such as abundance, low cost, renewability, excellent film-forming ability, good absorption capacity and great biocompatibility [14]. A bilayered human amniotic epithelial cells and Wharton’s jelly-derived mesenchymal stem cells-laden alginate/gelatin composite hydrogel was fabricated by a 3D bioprinting method This represents a potential preparation method for skin substitutes [18]. P. aeruginosa ATCC 27,853 was determined by measuring the zone of inhibition
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