Abstract
In this study, we aimed to synthesize a new photoluminescent nanocomposite based on hyperbranched polymers derived from arginine through an easy method for drug delivery application. Hence, a new hyperbranched polymer (HBPAC) via co-polymerization of citric acid (as A3 type monomer) and L-arginine (as AB2 type monomer) was synthesized and composited with glucose-derived quantum dot (GluQD) to obtain the HBPAC-GluQD nanocarrier. The HBPAC-GluQD was characterized, and its potential was studied as a nanocarrier. The particles size of the nanocomposite was about 90–200 nm. The antioxidant study of the HBPAC-GluQD revealed its excellent antioxidant properties. Also, the prepared HBPAC-GluQD showed photoluminescence (PL) in the blue range under 322 nm excitation with a QY of 72.8%. In vitro bioimaging investigations determined that HBPAC-GluQD has a potential for bioimaging applications. In-vitro release investigation of the HBPAC-GluQD nanocarrier exhibited that the composite has pH-responsive behavior and showed that the highest release happens at pH 5. Also, the stability, red blood cells compatibility, and MTT assay were evaluated. The obtained results showed that the HBPAC-GluQD as a nanocarrier is stable enough, biodegradable, and hemocompatible in physiological condition. Also, apoptosis, cellular uptake, and MTT analysis showed that the HBPAC-GluQD-DOX/MTX could efficiently induce cellular apoptosis.
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