Synthesis of a hydrophilic and non-ionic anthracene derivative, the N, N′-di-(2,3-dihydroxypropyl)-9,10-anthracenedipropanamide as a chemical trap for singlet molecular oxygen detection in biological systems

Glaucia R Martinez,Flávia Garcia,Luiz H Catalani,Jean Cadet,Mauricio C.B Oliveira,Graziella E Ronsein,Sayuri Miyamoto,Marisa H.G Medeiros,Paolo Di Mascio

doi:10.1016/j.tet.2006.08.094

Synthesis of a hydrophilic and non-ionic anthracene derivative, the N, N′-di-(2,3-dihydroxypropyl)-9,10-anthracenedipropanamide as a chemical trap for singlet molecular oxygen detection in biological systems

Glaucia R Martinez, Flávia Garcia + Show 7 more

https://doi.org/10.1016/j.tet.2006.08.094

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Journal: Tetrahedron	Publication Date: Sep 25, 2006
Citations: 35

Affiliation: Universidade de São Paulo, Joseph Fourier University, Université Grenoble Alpes, Atomic Energy and Alternative Energies Commission, CEA Grenoble

#Detection In Biological Systems #Singlet Molecular Oxygen + Show 8 more

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Abstract

We report herein the synthesis of a new hydrophilic and non-ionic anthracene derivative, the N, N′-di-(2,3-dihydroxypropyl)-9,10-anthracenedipropanamide. The evaluation of this compound as chemical trap of singlet molecular oxygen by using labeling experiments and HPLC–MS analysis showed that it could be efficiently used in biological investigations.

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