Abstract
9-Fluorenylmethoxycarbonyl-protected amino aldehydes could be efficiently prepared in good yields by using two methods: (i) NaBH 4 reduction of Fmoc-protected mixed anhydrides, followed by the Swern oxidation of the alcohols; and (ii) LiAlH 4 reduction of Fmoc-protected amino acid Weinreb amides. Both methods afforded comparable overall synthetic yields (70–80%).
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