A Tandem Isomerization–Mannich Reaction for the Enantioselective Synthesis of β‐Amino Ketones and β‐Amino Alcohols with Applications as Key Intermediates for ent‐Nikkomycins and ent‐Funebrine

Abstract

Abstractβ‐Amino ketones, with a primary amino group, are easily obtained in good yields and excellent enantioselectivities through a short sequence that involves, as a key step, a tandem isomerization–Mannich reaction from allylic alcohols with N‐tert‐butanesulfinimines. This method was used for the enantioselective synthesis of corresponding β‐amino alcohols and also for key intermediates in the preparation of ent‐nikkomycins or ent‐funebrine.