Synthesis of 4H-Pyran Derivatives via a Green One-Pot Multicomponent Reaction Catalyzed by CuFe2O4¬ Magnetic Nanoparticles as a Reusable Catalyst

Ali Maleki,Vahid Eskandarpour,Mina Ghassemi

doi:10.3390/ecsoc-18-a037

Abstract

Recently, environmental pollution and the economic crisis have become very important global challenges. Nowadays, industrial and manufacturing units including chemicals and pharmaceutical companies show propensity to environmentally friendly protocols that is so-called green and sustainable protocols. In this field, green chemistry plays an efficient role. One of the important strategies in green chemistry is multicomponent reactions (MCRs). On the other hand, catalysts are powerful tools to improve reaction conditions. Application of nanoscience in this field leads to a wide range of academic and industrial researches to obtain greenprocedures.2-Amino-4H-pyran derivatives are important molecules because of their biologicalactivities such asantiallergic, antitumor, antibacterial, diuretic, anti-coagulant, and anti-anaphylactic. Also reusability of catalysts is an important challenge in green chemistry. Magnetic nanoparticles (MNPs) are used as efficient catalysts, because they are easily separable and recyclable and have high surface area vs. bulk materials that improves their activity. In continuation of our interest in the application of new catalysts in organic synthesis via MCRs, herein, we represent an environmentally friendly synthesis of 4H-pyrans via a green one-pot threecomponent reaction using MNPs CuFe2O4 as catalyst under mild reaction conditions in good to excellent yields.

Highlights

4H-Pyran derivatives are an important class of heterocyclic compounds because of their biological and pharmaceutical activities [1]
The introduce of a new route for efficient synthesis of 4Hpyrans in mild conditions, short reaction times and ease of catalyst recycling is of prime importance
In this article, we have described a three-component reaction between aryl aldehydes, malononitrile, and a β-dicarbonyl compound in the presence a catalytic amount of MNPs at room temperature in ethanol

Summary

Introduction

4H-Pyran derivatives are an important class of heterocyclic compounds because of their biological and pharmaceutical activities [1]. Many methods were reported in the literature for the synthesis of 4H-pyrans including a two-step method containing cyclization of arylidene malononitriles with β-dicarbonyl compounds in the presence of catalysts such as MgO [3]. Most of these protocols suffer from long reaction times, difficulty of recovering the catalysts and the use of volatile solvents.

Results

Conclusion