Abstract
p-CF3BnSeCF2Br was developed as a bromodifluoromethylselenonating reagent, which was utilized by combining with mCPBA and Tf2O for the synthesis of 4-(bromodifluoromethylseleno) isocoumarins via the selenolation/lactonization of 2-alkynylbenzoates. The transformation was postulated to proceed via a multicomponent reagents system-enabled sequence involving the oxidation of p-CF3BnSeCF2Br by mCPBA into its selenium sulfoxide, activation of the generated sulfoxide by Tf2O into the electrophilic p-CF3BnSeOCF2Br salt, and selenolation/lactonization of 2-alkynylbenzoates by the reactive electrophilic species into 4-(bromodifluoromethylseleno) isocoumarins.
Published Version
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