Synthesis of 4-aryl-3-methyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridine-5-carbonitrile via a one-pot, three-component reaction

Abbas Rahmati

doi:10.1016/j.tetlet.2010.03.109

Synthesis of 4-aryl-3-methyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridine-5-carbonitrile via a one-pot, three-component reaction

Abbas Rahmati

https://doi.org/10.1016/j.tetlet.2010.03.109

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Journal: Tetrahedron Letters	Publication Date: Mar 31, 2010
Citations: 38

Affiliation: University of Isfahan

#Three-component Reaction #Toluenesulfonic Acid + Show 6 more

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Abstract

Abstract A one-pot, three-component condensation reaction of an aldehyde, 3-amino-5-methylpyrazole and ethyl cyanoacetate in ethanol to give 4-aryl-3-methyl-6-oxo-4,5,6,7-tetrahydro - 2 H - pyrazolo[3,4- b ]pyridine-5-carbonitriles, in high yields, at reflux, using a catalytic amount of p -toluenesulfonic acid, is described.

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