Abstract
Iminoester hydrochlorides 1 have been synthesized. These compounds were then converted into ester ethoxycarbonyl hydrazones 2, from which in turn a new series of substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones, 3, was then prepared. Finally a set of isatin imine derivatives 4 was obtained from the reaction of compounds 3 with isatin. The structures of all the new synthesized compounds were confirmed by elemental analyses, IR, 1H-NMR and 13C-NMR spectra.
Highlights
The synthesis and antibacterial activity of some 4-amino-4,5-dihydro-1H-1,2,4-triazoles and their derivatives have been reported in the literature [1-5]
The synthetic versatility of isatin has led to the extensive use of this compound in organic synthesis
Reactions of isatin with many amino compounds have been investigated, it appears that its reaction with the N-aminotriazole-5-ones have not been studied before
Summary
The synthesis and antibacterial activity of some 4-amino-4,5-dihydro-1H-1,2,4-triazoles and their derivatives have been reported in the literature [1-5].
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