Abstract

AbstractSynthesis of novel 4‐(4‐methylsulfonylphenyl)‐3‐phenyl‐2(3H)‐thiazole thione derivatives with functionalized diarylheterocycle pharmacophore as potential COX‐2 inhibitors was described. The title compounds were synth‐ esized by cyclocondensation of corresponding dithiocarbamate and 2‐bromo‐1‐(4‐methylsulfonylphenyl)ethanone, followed by dehydration with H2SO4. All of the target compounds were characterized by 1H NMR, IR and mass spectral data.

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