Abstract
AbstractA copper acetate‐mediated reaction of benzaldehydes with nitromethane to synthesis of 3‐nitroisoxazoles is reported. A variety of nitro‐aryl‐disubstituted isoxazole derivatives can be prepared in moderate to good yields with benign functional group tolerance. This protocol is successfully applied in gram‐scale reaction. Preliminary mechanistic studies reveal that the aldehyde provided one carbon atom for the isoxazole ring, and nitromethane provided two carbon atoms and one nitrogen atom for the isoxazole ring. In this protocol, the C−O−N unit in the final isoxazole ring is formed from the rearrangement of nitromethane.magnified image
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
