A Brief Review on Isoxazole Derivatives as Antibacterial Agents

Abstract

Isoxazole compounds exhibit a wide spectrum of targets and broad biological activities. Isoxazole derivatives are still popular scaffolds for the development of new agents with variable biological activities such as antimicrobial, antiviral, anticancer, anti-inflammatory, immunomodulatory, anticonvulsant or antidiabetic properties. The key feature of these heterocycles is that they possess the typical properties of an aromatic system but contain a weak nitrogen-oxygen bond which under certain reaction conditions like reducing or basic conditions is a potential site of ring cleavage. Thus, isoxazoles are very useful intermediates since the ring system stability allows the manipulation of substituents to give functionally complex derivatives, yet it is easily cleaved when necessary. In this review we have focused on the FDA approved antibacterial agents, clinically used drugs containing isoxazole moiety, Antibacterial agents with isoxazole moiety under preclinical trial, Isoxazole derivatives as antibacterial agents, FDA approved antibacterial agents with isoxazole ring, Mechanism of action of isoxazole derivatives, synthesis and screening of isoxazole derivatives as antibacterial agents Keywords: Isoxazole, Antibacterial activity, FDA approval, Chalcone