Abstract
AbstractHere we report a facile cyclization reaction of β,γ‐unsaturated ketones with NaNO2 under mild conditions to construct 3‐acyl‐isoxazoles. This transformation is realized via nitrosation of the activated methylene, radical 5‐endo trig cyclization, and then aromatization, according to some control experiments. Further, this protocol provided an efficient access to a variety of isoxazoles from readily available allyl ketones.
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