Abstract
The reaction of o-phthaloyl chloride with sodium diethylphosphite leads to the formation of cyclic bisphosphonate—a 3,3-bis(diethylphosphono)-1(3H)-isobenzofuranone. The hydrolysis of 1-(3H)-isobenzofuranone with aqueous potash results in the acyclic α−ketophosphonate. At the same time, hydrolysis with hydrochloric acid yields the bisphosphonic acid in a good yield. The reaction of 3,3-bis(diethylphosphono)-1-(3H)-isobenzofuranone with benzylamine in the presence of triethylamine passes with the replacement of endocyclic oxygen on PhCH2N group to give the bisphosphonate-phthalimide The structures of the compounds were confirmed by IR, 1Н, 13С, 31Р NMR spectroscopies, mass spectra, and in one case, a single crystal X-ray analysis.GRAPHICAL ABSTRACT
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Phosphorus, Sulfur, and Silicon and the Related Elements
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
