Abstract
Thiuram disulfides, many of them revealing various utilitarian properties, are among the most important classes of organic sulfur compounds. For instance, tetraethylthiuram disulfide (Teturam, Disulfiram) is used in medicine to treat chronic alcoholism, and tetramethylthiuram disulfide accelerates rubber cooling and has been intensively applied in the industry [1]. Tetramethylthiuram disulfide is used in preparation of antihypertensive drug clonidine as well. N,N-Bis(vinyloxyethyl)thiuram disulfide homopolymer obtained by cationic polymerization is a selective adsorbent of mercury and noble metals [2]. Despite the wide range of thiuram disulfides applications, only a limited number of such amine derivatives have been investigated so far. Therefore, it is of potential practical interest to synthesize thiuram disulfide based on 2-amino-4-phenylthiazole; that amine has been selected due to various pharmacological activities of the thiazoles: antiviral, anti-parasitic, and anti-pyretic drugs [3] are among other examples.
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