Synthesis of 2-deoxy- d-galactose containing gangliosides in vivo

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Incorporation of 2-deoxy- d-galactose into the oligosaccharide moieties of different gangliosides of rat liver was examined. After intraperitoneal administration of 2-deoxy- d-galactose it was shown by GLC/MS analysis that this hexose analogue is metabolized and incorporated into all the gangliosides investigated, and predominantly into G M3 and G D3. In both of these gangliosides, 25–55% of the galactose residues were substituted by 2-deoxy- d-galactose. The epimer, 2-deoxy-o-glucose, was not detectable.