Abstract
A novel series of 1-(2-(halophenyl)-2-(2-arylhydrazono)ethyl)-1H-1,2,4-triazoles 7a-l and their Fischer indolic products namely 2-(halophenyl)-3-(1H-1,2,4-triazol-1-yl)-1H-indoles 8a-l were synthesized conveniently. Furthermore, the (Z or E)-geometry of arylhydrazones was identified by 1H NMR spectroscopy. The antiepileptic potential of both series of compounds was studied by PTZ and MES seizure models. Based on the obtained data, most of hydrazones showed significant protective effect on MES-induced seizure model. Among them, compounds 7a and 7h were demonstrated to be the most potent ones against MES-induced seizures with rapid-acting properties. Generally, the indolic compounds showed less activity when compared to their original arylhydrazones.
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