Abstract
Cyclocondensation of the esters and amides of cyanoacetic acid with 1-spiro-cyclohexylcarbinols yielded derivatives of 2-(3-spiro-cyclohexyl-3,4-dihydroisoquinolyl-1)acetic acid containing and not containing methylenedioxo groups at positions 6,7. Compounds containing this group were found to increase blood clotting; those without it, conversely, decreased clotting. The most active compounds had effects comparable to those of ethamsylate and heparin.
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