Abstract
A series of 2-(3-spiro-cyclohexyl-3,4-dihydroizoquinol-1-yl)acetic acid derivatives containing methylenedioxo groups at positions 6,7 (or free of such groups) have been obtained via the reaction of cyclocondensation of cyanoacetic acid ether and amides with 1-spirocyclohexyl carbinols. Compounds containing said group increase the blood coagulation, while those deprived of this group, on the contrary, inhibit this process. For the most active compounds, the levels of activity are comparable with the effects of ethamsylate and heparin.
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