Synthesis of 14-Substituted-14H-Dibenzo[a,j]Xanthene Derivatives in Presence of Effective Synergetic Catalytic System Bleaching Earth Clay and PEG-600

Sandeep T. Atkore,Mufsir Kuniyil,Syed Farooq Adil,Mohammad Rafe Hatshan,Giribala M. Bondle,Vinod T. Kamble,Mohammed Althaf Hussain,Pranita V. Raithak,Baji Shaik,Ravi Varala

doi:10.3390/catal11111294

Abstract

The synthesis of 14-aryl 14H-dibenzo[a,j]xanthenes is achieved by a simple condensation reaction between β-naphthol with aryl or alkyl aldehydes in an effective synergetic catalytic system created by combining basic bleaching earth clay and PEG-600. The advantages of the present method include catalyst recyclability, superior product yield, a shorter reaction time and the avoidance of hazardous reagents. Synthesized xanthene derivatives were also screened for their antibacterial activity against Staphylococcus aureus (MTCC 96) and Pseudomonas aeruginosa (Wild).

Highlights

There has been considerable interest in the development and synthesis of xanthene derivatives because of their wide range of biological and pharmaceutical applications.Xanthene’s moiety exhibits a range of valuable properties that could be put to use in biological contexts, such as antiviral, antibacterial and anti-inflammatory properties [1].functionalized xanthenes, such as diversonol, globosuxanthone A and nidulalinA, are used as anticancer drugs (Figure 1).It should be mentioned, too, that benzoxanthene derivatives have shown beneficial functions as sensitizers in photodynamic therapy (PDT), as well as in controlling localized tumors [2]
The overall findings of this experiment are that the combination of PEG-600 with bleaching earth clay catalyst at 90 ◦ C
We have described a novel and efficient method for the preparation of 14-substituted

Summary

Introduction

There has been considerable interest in the development and synthesis of xanthene derivatives because of their wide range of biological and pharmaceutical applications.Xanthene’s moiety exhibits a range of valuable properties that could be put to use in biological contexts, such as antiviral, antibacterial and anti-inflammatory properties [1].functionalized xanthenes, such as diversonol, globosuxanthone A and nidulalinA, are used as anticancer drugs (Figure 1).It should be mentioned, too, that benzoxanthene derivatives have shown beneficial functions as sensitizers in photodynamic therapy (PDT), as well as in controlling localized tumors [2]. Xanthene’s moiety exhibits a range of valuable properties that could be put to use in biological contexts, such as antiviral, antibacterial and anti-inflammatory properties [1]. Functionalized xanthenes, such as diversonol, globosuxanthone A and nidulalin. It is noteworthy that the extended conjugation of this important group of oxygen heterocycles confers interesting spectroscopic properties which have many applications in laser technology [3] and dyes. These compounds can be used as luminescent sensors [4]. There are many reports on the synthesis of xanthene derivatives, including aryne cycloaddition to phenols [5], intramolecular coupling of aldehydes and ketones [6], cyclodehydration [7], the reaction of β-naphthol with formamide [8], 4.0/)

Methods

Results

Conclusion