Abstract

A rapid, green and efficient method for the synthesis of 1,8-dioxooctahydroxanthene and 3,3-arylidenebis(4-hydroxycoumarin) derivatives through a one-pot condensation from various aromatic aldehydes is described using manganese ferrite (MnFe 2 O 4 ) and cobalt ferrite (CoFe 2 O 4 ) as promoting material under solvent-free conditions which can easily be recovered and reused. Compared with other synthetic methods, this new method has advantages such as milder reaction conditions, good to excellent yields, short reaction times, and environmentally benign procedure.

Highlights

  • Synthesis of heterocyclic compound has a huge importance in chemistry, biochemistry, modern drug design, and these compounds are widely distributed in nature

  • Nowadays there are a lot of heterocyclic pharmaceuticals, these are used widely as antitumor, antiviral, antibiotic, antiHIV pharmaceuticals there is a large number of literatures about the synthesis of heterocyclic compounds have potential biological activity, but preparation of novel compounds and more efficient and economic methods means challenge for organic chemists

  • Apart from these applications, they are used in photodynamic therapy.3 view of the general observation that the biological activities are invariably associated with1,8-dioxooctahydroxanthenes and 3,3-arylidene bis(4-hydroxycoumarin) derivatives, in this work we describe a new method and promoter to prepare some derivatives belong to these compound classes

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Summary

INTRODUCTION

Synthesis of heterocyclic compound has a huge importance in chemistry, biochemistry, modern drug design, and these compounds are widely distributed in nature. Nowadays there are a lot of heterocyclic pharmaceuticals, these are used widely as antitumor, antiviral, antibiotic, antiHIV pharmaceuticals there is a large number of literatures about the synthesis of heterocyclic compounds have potential biological activity, but preparation of novel compounds and more efficient and economic methods means challenge for organic chemists. Xanthenes and their substituted derivatives are useful targets for chemical synthesis as they have been associated with a diverse range of therapeutic and pharmacological properties such as antiviral and antibacterial activity.. Xanthenes and their substituted derivatives are useful targets for chemical synthesis as they have been associated with a diverse range of therapeutic and pharmacological properties such as antiviral and antibacterial activity. Apart from these applications, they are used in photodynamic therapy. view of the general observation that the biological activities are invariably associated with1,8-dioxooctahydroxanthenes and 3,3-arylidene bis(4-hydroxycoumarin) derivatives, in this work we describe a new method and promoter to prepare some derivatives belong to these compound classes

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