Abstract
Synthesis of 1, 3-diaryl-2-propene-1-one derivatives using Tripotassium phosphate as an alternative and efficient catalyst and study its cytotoxic and antimicrobial properties
Highlights
A series of fourteen chalcone was synthesized via
We have developed method using tripotassium phosphate as an efficient green catalyst for the synthesis of chalcones
All results are in agreement with the structural confirmation. These compounds were screened for their antimicrobial activity
Summary
A series of fourteen chalcone was synthesized via. Claisen–Schmidt condensation between substituted 2- hydroxyl acetonaphthones and substituted benzaldehyde in presence of tripotassium phosphate (K3PO4) catalyst. They are biogenic key precursors of flavonoids in many plants[2, 3] They exhibit the wide range of biological properties such as antiviral, anti-inflammatory, antimicrobial[4,5], cytotoxicity[6-8], analgesic, antimitotic, antitumor, antiulcerative and antipyretic properties[9].The α,β-unsaturated ketones, possess reactive ketoethylenic group, which makes it enormous important in organic synthesis. These compounds are useful as intermediates for the synthesis of various heterocyclic compounds[10]. Available K3PO4 is found to be interesting catalyst for the synthesis of titled compounds since this is thermally stable and inexpensive 24 In view of these observations, for the first time we introduce a simple and convenient approach for chalcone synthesis using tripotassium phosphate in combination with 2-methoxyethanol as reaction solvent (Scheme 1, Table 5)
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