Abstract
New analogues of pulmonarin B were synthesized from (3,5-dibromo-4-hydroxyphenyl)acetic acid derivatives, and their antibacterial and antibiofilm activities against E. coli, S. aureus, and P. aeruginosa were evaluated. The antibacterial activity of synthesized ammonium salts against the methicillin-resistant strain of S. aureus 222 depends on the length of the alkyl chain. Bis-quaternary ammonium salt 5 demonstrated better activity against S. aureus 222, E. coli 311, and P. aeruginosa 449 compared to mono-alkylated derivatives. Analogues of pulmonarin B 5 and 4d reduced S. aureus 222 biofilm formation by 74.5% and 89.4%, respectively. In addition, compound 4c turned out to be the most active against the biofilm formation of P. aeruginosa 449 (biomass decreased by 39.8%).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
