Abstract
AbstractAn efficient and mild trifluoromethanesulfonic acid‐catalyzed hydroamination of unfunctionalized alkenes to afford α‐tertiary amine derivatives at temperatures as low as room temperature is reported. 2,2,2‐Trifluoroethyl sulfamate was found to be the optimal nitrogen source because its good solubility in both organic solvents and water facilitated both conversion and purification. The reaction conditions were compatible with a variety of substrate functional groups and afforded moderate to good yields. The desired amine compounds could be obtained easily by means of a mild, one‐pot, redox‐neutral deprotection procedure. Caryolane amine was synthesized with excellent chemo‐ and regioselectivities by means of a cascade hydroamination reaction of β‐caryophyllene.magnified image
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
