Synthesis, Molecular and Supramolecular Structure Aspects, and Antimicrobial Activity of the Centrosymmetric [Ag(5-Nitroquinoline)2]ClO4 Complex

Mezna Saleh Altowyan,Saied M Soliman,Aminah A Alkharboush,Nora Hamad Al-Shaalan,Assem Barakat

doi:10.3390/sym14030547

Mezna Saleh Altowyan, Saied M Soliman + Show 3 more

Open Access

https://doi.org/10.3390/sym14030547

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Abstract

The new homoleptic [Ag(5-nitroquinoline)2]ClO4 centrosymmetric complex was synthesized and its structure aspects were investigated. It crystallized in the monoclinic space group C2/c with a = 10.0279(2) Å, b = 13.2295(3) Å, c = 14.7552(3) Å and β = 102.1050(10)° while V = 1913.96(7) Å3 and half molecule as asymmetric formula. The Ag(I) is coordinated with two symmetrically related 5-nitroquinoline ligand units via the heterocyclic nitrogen atom with Ag-N distance of 2.146(6) Å and N1-Ag-N1 angle of 173.0(3)°. The two coordinated 5-nitroquinoline have anti configuration to one another and the perchlorate anion is set freely uncoordinated. The only Ag…O interactions are Ag1…O2 (3.110 Å) and Ag1…O1 (3.189 Å) which occur between the Ag(I) in one complex unit and the O-atoms from the NO2 groups in the neighbouring complex units. Hence, Ag(I) has coordination number 2 and its coordination geometry is slightly bent. Hirshfeld analysis indicated that the O…H (51.1%), C…H (11.8%), H…H (10.8%) and C…C (8.9%) contacts are the most common. Exclusively, the O…H, C…O, N…O, O…O and Ag…O contacts are the only shorter contacts than the vdWs radii sum of the interacting atoms. The studied Ag(I) complex showed good antimicrobial activity. It has comparable antibacterial activity against P. vulgaris (MIC = 9.7 μg/mL) and S. aureus (39.1 μg/mL) to Gentamycin (4.8 and 9.7 μg/mL, respectively) while better antifungal activity against A. fumigatus (MIC = 39.1 μg/mL) than Ketoconazole (156.2 μg/mL).

Highlights

Transition metals and their compounds have many applications in different areas of chemistry [1–3]
Before the discovery of antibiotics, silver nitrate solution was used as eye drops for new born children to avoid conjunctivitis [12,13]
Completeness to θ = 25.35° Refinement method Data/restraints/parameters Goodness-of-fit on F2 Final R indices [I > 2sigma(I)] R indices Largest diff. peak and hole

Summary

Introduction

Transition metals and their compounds have many applications in different areas of chemistry [1–3]. Silver is one of the coinage metals which is acknowledged to have interesting applications in biology [4–11]. Silver compounds were used as an antibiotic coat for medical devices [14–17]. Ag and its compounds have promising applications in wound dressing and as cream to treat external infections [14–16]. For example silver sulfadiazine (SSD) and nanosilver compounds have great interest in wound dressing to treat external infections [11,17,18]. In the light of this interesting features of silver in its different forms, scientist recommended Ag(I) complexes as a solution for the problems associated with. Symmetry 2022, 14, x Symmetry 2022, 14, 547 scientist recommended Ag(I) complexes as a solution for the problems associated with mmuullttiiddrruugg--rreessisistatannt tbbaaccteterriaial lssttrraaininss((MMDDRRSS))[[2222,2,233]]. 985, 1626, 1592, 1520, 1320, 1242, 1208, 1134, 1073, 1047 (Figure S1, Supplementary Materials). Further experimental details are given in the Supplementary Materials (Method S1) [39]

Results and Discussion

Hirshfeld Analysis

FTIR Spectra

Antimicrobial Activity

Conclusions