Abstract
Some metal(II) complexes of the mixed drugs-Aspirin and Vitamin B2 (Riboflavin) were synthesized and characterized by melting point, conductance, percentage metal measurements, as well as infrared and electronic spectroscopies. The electronic spectra, percentage metal analysis and conductance measurements corroborated octahedral geometry for all the metal complexes. Infrared data confirmed that metal complexes had O4 chromophores, that is, coordination was via the carbonyl oxygen atoms of the carboxylic acid and acetyl groups of the Aspirin; and hydroxy oxygens in Riboflavin. Furthermore, the room temperature magnetic data suggested that both the Fe(II) and the Ni(II) complexes exhibited spin-crossover, that is, low spin ↔ high spin octahedral equilibrium, while the Mn(II) and Cu(II) complexes exhibited antiferromagnetism respectively. The drugs, Aspirin and Vitamin B2, and their metal(II) complexes were generally inactive against E.coli, Enterobacteria sp, Klebsiella sp, Bacillus sp, Staphylococcus aureus, Pseudomonas sp and Staphylococcus epidermidis, with the exception of Co(II), Ni(II) and Cu(II) complexes which showed some activities against Bacillus sp., Klebsiella sp. and Staphylococcus spp. with inhibitory zones in the range of 6.0 - 12.0 mm respectively.
Highlights
Metal complexes are the focus of drug designs due to the success of metallo drugs like Auranofin, Flamazine and Cis-platin[1]
Literature is available on metal complexes of individual analgesics and vitamins including Aspirin and Riboflavin[7,8,9,10]
The melting points of the ligands and their metal(II) complexes were distinctively different, that is, Aspirin decomposed at 1360C, Vitamin B2 melted at 2800C, and the metal complexes mostly decomposed above or below the melting point and decomposition temperature of their respective parent drugs due to coordination
Summary
Metal complexes are the focus of drug designs due to the success of metallo drugs like Auranofin, Flamazine and Cis-platin[1] This has expanded the data base on chemo therapeutic agents which are less toxic, with improved anticancer, antioxidant and antimicrobial activities. Our aim was to synthesize the metal(II) complexes of the mixed drugs-Aspirin and Riboflavin{M = Mn, Fe, Co, Ni, Cu & Zn} and investigate their magnetic properties for cooperative phenomena (spin crossover, ferro- and anti-ferromagnetisms). In addition their antibacterial properties against some pathogenic bacteria were verified for their suitability as broad-spectrum antibacterial agents
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