Synthesis, identification, antibacterial activity and laser effect of new derivatives of bis-1,3-oxazepene-4,7-dione and 1,3-diazepine-4,7-dione

Abstract

In the current study, Schiff bases [F1-F3] compounds have been prepared by terephthalaldehyde reaction with aniline and its p-substituted aniline (4-chloro aniline and 4-hydroxy aniline) in absolute ethanol. Then, Schiff bases were converted into 1,3-oxazepine-4,7-dione derivatives [F4-F6] by reacting with 3,4-dimethylfuran-2,5-dione in dry benzene.1,3-Oxazepine-4,7-dione derivatives were transformed to 1,3-diazepine-4,7-dione derivatives [F7-F9] through a reaction with 2-nitro aniline. The prepared compounds have been characterized by physical properties, UV-Vis, FT-IR, 1H-NMR spectral and (C.H.N-O) analysis. TLC was tested for the purity of these compounds. The antibacterial activities against Escherichia coli and Klebsiella pneumonia Gram negative, Staphylococcus aureus and Staphylococcus epidermidis Gram positive, and evaluation of laser efficacy have been shown for the compounds [F1-F9].The laser was radiated for (10, 20, 30) seconds. It was noted that when the melting point and color were determined, the compounds have not been affected and they have not been disintegrated or polymerized.