Preparation, diagnostics and biological evaluation of new Schiff base and tetrazole derivatives

Abstract

In this study, new Schiff bases [E1-E5] compounds were prepared by substituting para-benzaldehyde with the 4,4-(Diazene-1,2-diyl) dianiline compound absolute ethanol. Schiff bases then were converted into tetrazole derivatives [E6-E10] by reacted with sodium azide in absolute ethanol. The prepared compounds were characterized by physical properties, UV–Vis, FT-IR and 1H NMR, 13C NMR spectral and C.H.N analysis. TLC checked the purity of these compounds. The antibacterial activities were studied against bacteria, namely Pseudomonas aeruginosa Gram (-) ve and Staphylococcus aureus Gram (+) ve. The optical microscope polarization has been studied in the liquid crystal phases. The values of the thermal transfer degrees of the liquid and isotropic crystal phases were assigned to most of some prepared compounds [E3, E5, E6, E7, E10], and the nature of these transitions was studied. The liquid crystal shapes were diagnosed using a heated polarized light microscope.