Abstract
A series of novel 3-{[(5-phenyl-1,3,4-thiadiazol-2-yl)imino] methyl}quinoline-2-thione (2a–c) and 2-phenyl-3-pyrido[3,2][1,3,4]thiadiazolo[3,2]quinoline derivatives (3a–c) were prepared by a facile synthetic method using an anhydrous potassium carbonate catalyst. The newly synthesized heterocyles were characterized by elemental analysis, FT-IR, 1H-NMR, and mass spectral data. The selected compounds were studied for interaction with calf thymus-DNA(CT-DNA) by electronic spectra and viscosity measurements, as well as thermal denaturation studies. Upon binding to DNA, the absorption spectrum underwent bathochromic and hypochromic shifts. The binding constant (Kb) observed value of 8.4 × 105 M−1 for (2a) and 8.2 × 105 M−1 for (3a) suggested that compound (2a) binds more avidly to CT-DNA than compound (3a). The increasing viscosity of sonicated rod-like DNA fragments and the melting temperature of DNA, in the presence of compound solutions, support the binding mode. The synthesized derivatives have been screened for antibacterial and antifungal activities.
Published Version
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