Synthesis, Crystal Structures, and Biological Activity of Cu(II), Mn(III), and Fe(III) Complexes Derived from N,N’-Bis(4-methoxysalicylidene)ethylenediamine

Abstract

Three mononuclear copper(II), manganese(III), and iron(III) complexes, [CuL(OH2)] (1), [MnClL] (2), and [FeClL] (3), where L is the deprotonated form of N,N’-bis(4-methoxysalicylidene) ethylenediamine, were synthesized and structurally characterized by physicochemical methods and single-crystal X-ray diffraction. Each metal atom in the complexes adopts a square pyramidal coordination, with the four donor atoms of the Schiff base defining the basal plane, and with the water molecule for 1, and chloride atom for 2 and 3 occupying the apical position. The complexes were evaluated in vitro for their inhibitory activities against Jack bean urease. The copper complex showed effective inhibitory activity against the urease. A docking simulation was performed for the copper complex into the active site of the urease to investigate the probable binding conformation.