Abstract
A cobalt (III) complex [Co(bpy)2CO3](PNP)·4H2O (C1) (where PNP=Paranitrophenolate, bpy = 2,2’-bipyridine) has been synthesized, characterized by analytical and spectroscopic techniques and further characterized structurally by single crystal X-ray analysis. C1 crystallizes in a monoclinic crystal system with space group P21/c. The cobalt atom arranges in a distorted octahedral geometry by coordinating to four nitrogen atoms from two bipyridine and two oxygen atoms from carbonato group. Non-covalent interactions like O–H⋯O (water/phenolate), O–H⋯O (water/water), C–H⋯O (aromatic-nitro) and C–H···π interactions exist in the crystal lattice. Futhermore, the anticancer potential against PANC-1 cells and hTERT-HPNE cells has been carried out by MTT assay. The results revealed that the complex showed significant and dose dependent anticancer activity for PANC-1 cells and no significant cytotoxicity for hTERT-HPNE cells. The antibacterial activity of the complex has also been tested against some gram positive and gram negative bacteria by disc diffusion method.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
