Abstract
A cobalt (III) complex [Co(bpy)2CO3](PNP)·4H2O (C1) (where PNP=Paranitrophenolate, bpy = 2,2’-bipyridine) has been synthesized, characterized by analytical and spectroscopic techniques and further characterized structurally by single crystal X-ray analysis. C1 crystallizes in a monoclinic crystal system with space group P21/c. The cobalt atom arranges in a distorted octahedral geometry by coordinating to four nitrogen atoms from two bipyridine and two oxygen atoms from carbonato group. Non-covalent interactions like O–H⋯O (water/phenolate), O–H⋯O (water/water), C–H⋯O (aromatic-nitro) and C–H···π interactions exist in the crystal lattice. Futhermore, the anticancer potential against PANC-1 cells and hTERT-HPNE cells has been carried out by MTT assay. The results revealed that the complex showed significant and dose dependent anticancer activity for PANC-1 cells and no significant cytotoxicity for hTERT-HPNE cells. The antibacterial activity of the complex has also been tested against some gram positive and gram negative bacteria by disc diffusion method.
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