Abstract
A new Au(III) complex was synthesized from an amidrazone derivative and HAuCl4. Cyclization of amidrazone moiety lead to the 1,2,4-triazolo[1,5a]pyridine ring system, followed by Au(III) chelation. The crystal and molecular structure of the final compound was studied by single crystal X-ray diffraction as well as by 1H13C and 1H15N HMQC- and HMBC-NMR spectroscopy, which resulted in the assignment of all detected signals. This species was tested in vitro as an antibacterial and antiproliferative agent. It exhibited good antibacterial activity against Staphylococcus aureus and was proved to be more potent than amoxicillin against Bacillus subtilis and the drug resistant strain of Klebsiella pneumoniae. In contrast, its antiproliferative properties against cancer cell lines A549, HT-29, MV-4-11 and MCF-7 were relatively low.
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