Synthesis, Characterizationand Antibacterial Activity of Quaternary Ammonium Compounds Bearing Mixed N-Substituted Groups

Abstract

Sixteen quaternary ammonium bromides [QAB]4(a-d)-7(a-d)bearing mixed N-branches were synthesized by treating n-butyl 2a, cyclohexyl 2b, 2,3,4,6-tetra-O-acetyl – Dglucosyl 2c and cholesteryl 2d bromides, separately with n-butyl amine 3a, benzyl amine 3b, N,N-dimethyl amino ethyl-2methyl acrylate 3c and N,N-diethyl amino ethyl-2methyl acrylate 3d. N,N-Diphenyl amine 3e failed to react with any bromides within the scope of this work. The synthesized bromides and QAB were characterized by FT-IR, H-NMR and C-NMR. All compounds were tested for their activity against some gram-positive and gram-negative bacteria and some of them exhibited significant antibacterial activities.