Abstract
Two new and similar cobalt(III) complexes, [CoL2]·NO3 (1) and [CoL2]·Cl (2), where L is 5-bromo-2-((2-(phenylamino)ethylimino)methyl)phenolate, have been synthesized and characterized by IR and UV-Vis spectra. Structures of the complexes were confirmed by single crystal X-ray determination. The Co atoms in the complexes are in octahedral coordination, with the donor atoms come from the two Schiff base ligands, viz. phenolate oxygen, and imino and amino nitrogen. The anions of the cobalt salts crystallized as counteranions in the complexes. The complexes were assayed for antibacterial activities by MTT method.
Highlights
Schiff bases due to their facile synthesis and interesting biological activities, have attracted considerable attention in inorganic and biological chemistry
The Schiff base HL was readily prepared by the reaction of 4-bromosalicylaldehyde and N-phenylethane -1,2-diamine in methanol (Scheme 1)
The complexes were prepared in a similar method, by the reaction of the Schiff base ligand with cobalt nitrate and cobalt chloride, respectively (Scheme 2)
Summary
Schiff bases due to their facile synthesis and interesting biological activities, have attracted considerable attention in inorganic and biological chemistry. A number of Schiff base compounds have shown antifungal, antibacterial, antiproliferative, and antitumor activities.[1] Schiff base compounds possess N and O donor atoms, are important ligands in coordination chemistry. The antibacterial activity of the compounds against Gram-positive bacterial strains (B. subtilis, S. aureus and St. faecalis) and Gram-negative bacterial strains (E. coli, P. aeruginosa and E. cloacae) by MTT method was studied
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