Abstract
A centrosymmetric O-bridged polynuclear copper(II) complex, [CuL2]n, where L is the deprotonated form of the Schiff base ligand 2-hydroxy-5-methylbenzaldehyde oxime, has been prepared and characterized by IR, UV and single-crystal X-ray determination. There is a crystallographic inversion center in the complex. The Cu atom in the complex is coordinated by the phenolate oxygen, imino nitrogen and hydroxyl oxygen atoms from two Schiff base ligands, forming octahedral geometry. The complex was tested in vitro for its antibacterial activity.
Highlights
Schiff bases are readily synthesized by the condensation reaction of carbonyl compounds with primary amines.[1]
The Schiff base hydroxy-5-methylbenzaldehyde oxime (HL) was readily prepared by the reaction of 2-hydroxy-5-methylbenzaldehyde with hydroxylamine in ethanol
The copper complex was prepared by reaction of equimolar quantities of the Schiff base ligand and copper perchlorate hexahydrate in ethanol
Summary
Schiff bases are readily synthesized by the condensation reaction of carbonyl compounds with primary amines.[1] Schiff bases have been widely investigated for their biological activities, such as antibacterial and antitumor activities,[2] biomimetic catalytic properties, etc.[3] Metal complexes of Schiff bases have been received much attention. These complexes play an important role in the development of coordination chemistry related to catalysis and enzymatic reactions, magnetism and molecular architectures,[4] and exhibit interesting biological activities.[5]. The antibacterial activities against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescens, were evaluated for the Schiff base and the copper complex
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