Abstract
This study involves the preparation of various organic compounds. Ethylnyl 2-((5-chloroquinolin8-yl)oxy)acetate compound (A1) was synthesized by adding Potassium carbonate to quinoline and ethyl chloroacetate. The 2-((5-Chloroquinolin-8-yl)oxy) acetohydrazide (A2) was prepared by reacting compound (A1) with hydrazide. Complex of (A3) were obtained by reacting equimolar amounts of compound (A2) with the Platinum salt solution of using ethanol as the solvent. Phosphinate complexes were prepared by reacting equal moles of the complex (A3) with the various phosphines used and using ethanol as a solvent. The synthesized compounds and complexes were characterized using various spectroscopic techniques, including Fourier-Transform Infrared (FT-IR) spectroscopy, Uv-Vis spectrum and Nuclear Magnetic Resonance (31P, 1H, and 13C-NMR) spectroscopy. Additionally, their melting points, purity, molar conductivity, and magnetic susceptibility were determined. The impact of some prepared compounds and complexes on the growth of two antibiotic-resistant bacterial strains, namely the Gram- positive Staphylococcus and the Gram- negative Escherichia coli, was studied. Ciprofloxacin was used as control antibiotics. Some of the synthesized compounds exhibited significant inhibitory activity against the tested bacterial strains.
Published Version
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