Abstract
This study was intentional to assess the antioxidant activity of various Schiff and Mannich bases derivatives of 2, 4-thiazolidinedione. Thiazolidinone and Thiazolidinedione is the first parent compounds in which thiazole ring was recognized. The compounds carrying the thiazolidinone ring have reported to demonstrate a wide range of pharmacological activity which includes the antimicrobial, antifungal, antitubercular, antitumor and antidiabetic activities. A series of Schiff and Mannich base derivatives of 2, 4-thiazolidinedione were synthesized to get more potent antioxidant activity. The starting material for the synthesis of various Schiff and Mannich base derivatives was 2, 4- thiazolidinedione which in turn was prepared from condensation of thiourea with chloroacetic acid in presence of hydrochloric acid. The structures of newly synthesized compounds were characterized by using TLC, IR and NMR spectroscopy. Antioxidant activity of 2, 4-thiazolidinedione derivatives were measured by DDPH (2, 2-diphenyl-1-picryl hydrazyl) assay and was compared to ascorbic acid as standard. The DDPH assay revealed that compound (JS-3 and JS-5) showed better antioxidant activity.
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