Synthesis, Characterization, Crystal Structure, and Cytotoxicity of a Diorganotin(IV) Complex with 2-Acetylpyridine N 4-Phenylthiosemicarbazone

Abstract

A new diorganotin(IV) complex formulated as [(Me)2Sn(L) (CH3COO)] (1), where HL = 2-acetylpyridine N(4)-phenylthiose micarbazone, has been synthesized and characterized by elemental analysis, IR spectra, and single-crystal X-ray diffraction studies. Schiff base in its deprotonated form coordinates to tin(IV) via pyridine nitrogen atom and the nitrogen atom and sulfur atoms of the thiosemicarbazone moiety. The tin(IV) ion is seven-coordinated and adopts a distorted pentagonal bipyramidal geometry. Biological studies, carried out in vitro against the K562 leukemia cells, have shown that the coupling of HL to Me2Sn(IV) leads to an enhancement of the cytotoxicity of the free ligand.