Abstract
A new hydrogen bonded Cobalt(II) Schiff base complex, N’-(pyridine-4-carboxaldehyde) isonicotinoylhydrazone Cobalt(II), has been synthesized from isoniazid and pyridine-4-carboxaldehyde and characterized by IR spectroscopy, 1H-NMR, elemental analysis, TGA and single crystal X-ray structure determination. X-ray crystal structure analysis shows an octahedral complex with a metal centre coordinated to two ligand molecules through the pyridine nitrogen atoms and four water molecules and containing two nitrate groups as counter ions. The complex crystallizes in the monoclinic crystal system and P2(1)/n space group. The unit cell dimensions are: a = 7.2108(4) A, b = 16.6020(9) A, c = 13.0389(6) A,α = 90°, β = 103.972(4)°, γ = 90°. The molecule is symmetrical about the cobalt centre as observed from the 1H-NMR and 13C-NMR and confirmed by the single crystal X-ray structure of the complex. Thermogravimetric analysis shows two steps decomposition of the complex to leave a metal oxide residue. The title compound is expected to be biologically active as one of the precursors (isoniazid) is a therapeutic agent with well-established clinical applications.
Highlights
Schiff bases display a variety of coordination modes, and have attracted a lot of attention in the development of coordination Chemistry [1] [2]
The molecule is symmetrical about the cobalt centre as observed from the 1H-NMR and 13C-NMR and confirmed by the single crystal X-ray structure of the complex
The air stable ligand, N’-(pyridine-4-carboxaldehyde) isonicotinoylhydrazone was obtained as a cream coloured powder
Summary
Schiff bases display a variety of coordination modes, and have attracted a lot of attention in the development of coordination Chemistry [1] [2]. The Schiff bases display varying degrees of flexibility and adopt different coordination modes in different complexes [3] [4] [5], the most common being the bidentate modes. Owing to their structural flexibility, tridentate [6], tetradentate [7] [8], pentadentate [9] and even hexadentate [10] coordination modes have been reported, and the flexible ligands have been employed in order to gain access to topologies not available from logical combination of rigid building blocks. The cobalt Schiff base complexes are an important class of coordination compounds, because of their involvement in Vitamin B12 models and oxygen carrier properties, and due to their interesting magnetic and spectroscopic as well as diverse metal-ligand interactions [5] [12]
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