Synthesis, characterization, crystal structure, and biological activity of the copper complex

Abstract

This work reports the synthesis and biological activity of the copper complex with 2–thenoyltrif-luoroacetone (HTTA). The complex was characterized by elemental analysis, infrared spectroscopy, and thermogravimetric analysis. The crystal structure was determined by single-crystal X-ray diffraction. The complex exists as a parallelogram with four coordination sites occupied by the carbonyl oxygen atoms from HTTA. The antibacterial activity test shows that the complex exhibits better antibacterial ability against Escherichia coli and Staphylociccus aureus (MIC were about 180, 150 μg/ml, respectively) and can be considered as broad-spectral antimicrobial. The antitumor activity of the copper(II) complex is tested by methyl thiazolyl tetrazolium assays against human Leukemia cells K562. The copper(II) complex exhibits potent antitumor effects against K562 cell lines. The IC50 value of the complex is about 0.01 μg/ml. The research shows that the complex can inhibit K562 tumor cell growth and generation and induce apoptosis. The inhibition ratio is accele by increasing the dosage and has a significant positive correlation with medication dosage.