Abstract
Mixed ligand complexes of Ni(II) with 1,10-phenanthroline (1,10-Phen) and Schiff bases L1(MIIMP); L2(CMIIMP); L3(EMIIMP); L4(MIIMNP); L5(MEMIIMP); L6(BMIIMP); L7(MMIIMP); L8(MIIBD) have been synthesized. These metal chelates have been characterized by elemental analysis, IR, 1H-NMR, 13C-NMR, Mass, UV-Vis, magnetic moments, and thermogravimetric (TG&DTA) analysis. Spectral data showed that the 1,10-phenanthroline act as neutral bidentate ligand coordinating to the metal ion through two nitrogen donor atoms and Schiff bases acts as monobasic bidentate coordinating through NO donor atoms. All Ni(II) complexes appear to have an octahedral geometry. The antimicrobial activity of mixed ligand complexes has been studied by screening against various microorganisms, it is observed that the activity enhances upon coordination. The DNA binding studies have been investigated by UV-Vis spectroscopy, and the experimental results indicate that these complexes bind to CT DNA with the intrinsic binding constant Kb = 2.5 ± 0.2 × 105 M−1. MTT is used to test the anticancer effect of the complexes with HL60 tumor cell. The inhibition ratio was accelerated by increasing the dosage, and it had significant positive correlation with the medication dosage.
Highlights
One of the major applications of the transition metal complexes is their medical testing as antibacterial and antitumor agents aiming toward the discovery of an effective and safe therapeutic regimen for the treatment of bacterial infections and cancers
To design effective chemotherapeutic agents and better anticancer drugs, it is essential to explore the interactions of metal complexes with DNA [14]
It is well known that some drug activities, when administered as metal complexes, are being increased, and several Schiff base complexes have been shown to inhibit tumor growth
Summary
One of the major applications of the transition metal complexes is their medical testing as antibacterial and antitumor agents aiming toward the discovery of an effective and safe therapeutic regimen for the treatment of bacterial infections and cancers. Many Schiff base complexes with metals have provoked wide interest because they possess a diverse spectrum of biological and pharmaceutical activities, including antitumor, antioxidative, antifungal, and antibacterial activities [1,2,3,4,5,6,7,8,9,10]. Schiff bases and their complexes have been used as biological models to understand the structures of biomolecules and biological processes [11, 12]. The incorporation of transition metal into Schiff bases enhances the biological activity of the ligand and decreases the cytotoxic effects of both the metal ion and ligand on the host [15]
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