Abstract
The copper(II) azo-dye Schiff base complex (CuL(OAc))2, was prepared and characterized on the basis of el- emental analyses, spectral, magnetic, molar conductance and thermal analysis. Square-planar geometry has been assigned to the prepared complex. Dimeric complex is obtained with 2:2 molar ratio. The IR spectrum of the prepared complex was suggested that the Schiff base ligand (HL) behaves as a bi-dentate ligand through the azomethine nitrogen atom and phenolic oxygen atom. Thermal properties and decomposition kinetics of copper(II) complex was investigated. The interpretation mathematical analysis and evaluation of kinetic parameters (E,A, ΔH, ΔS and ΔG) of all thermal decomposition stages have been evaluated using Coats-Redfern (CR), Horowitz-Metzger (HM) and Piloyan-Novikova (PN) equations. In molecular modeling the geometries of ligand HL and its copper(II) complex was fully optimized with respect to the energy using the 6-31G basis set. The pathogenic activities of the synthesized com- pounds were tested in vitro against the sensitive organisms Staphylococcus aureus (RCMB010027), Staphylococ- cus epidermidis (RCMB010024) as Gram positive bacteria, Klebsiella pneumonia (RCMB 010093), Shigella Flexneri (RCMB 0100542), as Gram negative bacteria and Aspergillus fumigates (RCMB 02564), Aspergillus clavatus (RCMB 02593) and Candida albicans (RCMB05035) as fungus strain, and the results are discussed.
Highlights
Medical inorganic chemistry has exploited the unique properties of metal ions for the design of new drugs [1]
EPR spectra of Cu(II) complex was recorded as polycrystalline sample and in the DMSO solution, at room temperature (RT) on E4-EPR spectrometer using the DPPH as the g-marker
The molar conductivity at room temperature of 10‒3 M solutions of complex in DMSO was at 16 Ω‒1 cm2 mol‒1 corresponding to nonelectrolyte
Summary
Medical inorganic chemistry has exploited the unique properties of metal ions for the design of new drugs [1]. Sulfur ligands are wide spread among coordination compounds and are important components of biological transition metal complexes [3]. Metal complexes with sulfur containing unsaturated ligands are of a great interest in inorganic and organometallic chemistry, especially due to their potential with novel electrical and magnetic properties [3]. Schiff bases continue to occupy an important position as ligands in metal coordination chemistry [4], even almost a century since their discovery. In continuation to our interest to prepare azo-dye Schiff bases [12,13] the present paper aims to prepare azo-dye Schiff base HL. The behavior of this ligand toward copper (II) ion was studied. The characterization of the prepared compounds was performed using different physicochemical methods
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