Abstract
Schiff base ligand and its Cu (II) Complex had been synthesized by the condensation reaction of 4-chloro-o-phenylene diamine and 2-hydroxy acetophenone. The Structure and spectral properties of ligand and complex were confirmed by UV, FT-IR and 1H NMR Spectroscopy. The spectral properties showed that it was a square planar geomentry with a tetradentate ligand. The Schiff base Cu (II) Complex was subjected to antimicrobial studies. In this paper I have taken to discuss these three bactericidal organisms such as Bacillus subtilis, Streptococcus viridians and Staphylococcus epidermidis on the test compounds. Schiff base Copper (II) complex were screened by employing the Disc Diffusion method. A concentration gradient (5, 10, 20 and 30mg/ml) of each compound was put into study. From the study, it was observed that it showed a maximum zone of inhibition. The Schiff base complex were subjected to analgesic studies and it showed a significant increase in analgesic activity when compared with normal saline. The Schiff base complex was subjected to CNS studies and it showed a depressant activity when compared with standard drug chlorpromazine. Keywords: Schiff Base, 4-Chloro-O-Phenylene Diamine, Electronic Spectroscopy, Petri Plates and CNS.
Highlights
Schiff bases are condensation products of primary amines with carbonyl compounds and they were first reported by Schiff [1] in 1864 (Schiff 1864 p. 118)
The Schiff base complex were subjected to analgesic studies and it showed a significant increase in analgesic activity when compared with normal saline
In studies concerning quantitative structure-antitumor activity relationship of a series of Schiff bases derived from variously substituted aromatic amines and aldehydes, it has been shown that azomethines from salicylaldehydes gave the best correlation [21], [22]
Summary
Schiff bases are condensation products of primary amines with carbonyl compounds and they were first reported by Schiff [1] in 1864 (Schiff 1864 p. 118). Schiff bases are condensation products of primary amines with carbonyl compounds and they were first reported by Schiff [1] in 1864 The common structural feature of these compounds is the azomethines group with a general formula RHC=N-R1, where R and R1 are alkyl, aryl, cyclo alkyl or heterocyclic groups which may be variously substituted. 1553) Schiff bases have been known since 1864 when Hugo Schiff reported the condensation of primary amines with carbonyl compounds. In studies concerning quantitative structure-antitumor activity relationship of a series of Schiff bases derived from variously substituted aromatic amines and aldehydes, it has been shown that azomethines from salicylaldehydes gave the best correlation [21], [22]. They were reported to possess antiviral, anti-HIV, antiprotozoal and antihelmintic activities. This paper presents the condensation reaction of 4-chloro-o-phenylene diamine and 2-Hydroxy acetophenone and Schiff base copper (II) Complex were prepared and further study were investigated
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