Synthesis, Characterization and Study Biological Activity of Five and Seven Heterocyclic Compounds

Abstract

The compound 3-((1-(naphthalene-2-yl) ethylidene) amino)-2-thioxo-imidazolidin–4-one [II] was prepared from the cyclization of 2-(1-(naphthalen-2-yl) ethylidene) hydrazine-1-carbothioamide [I] with ethyl α-chloroacetate in the presence of fused CH3COONa. The new 2-thioxo-imidazlidin-4-one derivatives containing heterocyclic unit, five, and seven-member ring were successfully formed, such as imidazoline-4-one, tetrazole, thiazolidin-4-one, and 1,3-oxazepinerings. The synthesized derivatives were characterized by their fourier-transform infrared spectroscopy (FTIR), 1H-NMR, mass spectra, and CHN-S. Furthermore, the synthesized compounds have been screened for their antibacterial activity against E.col (G-), Staph. Aureus (G+), and Bacillus cereus(G+), and compared to Ampicillin, Amoxicillin, and Lincomycin as antibiotic standards. How to cite this article: Neshan, F.A., Al-Rawi, M.S. and Tomma, J.H. (2019). Synthesis, Characterization and Study Biological Activity of Five and Seven Heterocyclic Compounds. International Journal of Drug Delivery Technology, 9(4): 587-592. Source of support: Nil. Conflict of interest: None.