Synthesis, Characterization, and Physicochemical Studies of Mixed Ligand Complexes of Inner Transition Metals with Lansoprazole and Cytosine

Sarika Verma,Rashmi Shrivastva,Sarita Shrivastva

doi:10.1155/2013/309179

Abstract

Few complexes of inner transition metals [Th(IV), Ce(IV), Nd(III), Gd(III)] have been synthesized by reacting their metal salts with lansoprazole, 2-([3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl)-1H-benzoimidazole and cytosine. All the complexes were synthesized in ethanolic medium. The yield percentage rangs from 80 to 90%. The complexes are coloured solids. The complexes were characterized through elemental analyses, conductance measurements, and spectroscopic methods (FT IR, FAB Mass,1H NMR and UV). An IR spectrum indicates that the ligand behaves as bidentate ligands. The metal complexes have been screened for their antifungal activity towardsAspergillus nigerfungi. The interaction of inner transition metals with lansoprazole, in presence of cytosine, has also been investigated potentiometrically at two different temperatures26±1°C and36±1°C and at 0.1 M (KNO3) ionic strength. The stability constants of ternary complexes indicate the stability order as Th(IV) < Ce(IV) < Gd(III) < Nd(III).logKvalues obtained are positive and suggest greater stabilization of ternary complexes. The values of thermodynamic parameters (free energy (ΔG), enthalpy (ΔH), and entropy (ΔS) are also calculated.

Highlights

Inner transition metal complexes are of continuing interest mainly due to their structural and catalytical properties and their application in diagnostic pharmaceutical and laser technology [1,2,3]. ey have been found to exhibit anticancer and fungicidal properties [4].Investigations are going on the formation of metal complexes with benzimidazole ring containing ligands because benzimidazole and its derivatives play an important role in analysis and in several biological reactions [5]
As the interaction of metal ions with nucleobases is of great interest because of their relevance to the essential, medical or toxic bioactivity of metal, where nucleobase molecule can coordinate as exogenous ligands in metalloproteins, function as cofactors in the enzymatic systems. us, cytosine is selected as the secondary ligand for the formation of ternary complexes
Stability of Complexes. e Δ log KK values obtained in the present study are positive indicating greater stabilization of ternary complexes

Summary

Introduction

Inner transition metal complexes are of continuing interest mainly due to their structural and catalytical properties and their application in diagnostic pharmaceutical and laser technology [1,2,3]. ey have been found to exhibit anticancer and fungicidal properties [4]. Inner transition metal complexes are of continuing interest mainly due to their structural and catalytical properties and their application in diagnostic pharmaceutical and laser technology [1,2,3]. Investigations are going on the formation of metal complexes with benzimidazole ring containing ligands because benzimidazole and its derivatives play an important role in analysis and in several biological reactions [5]. Considering the importance of drugs and their complexes it has been desired to synthesize and characterize some ternary complexes of inner transition metal [ (IV), Ce(IV), Gd(III), Nd(III)] with a Benzimidazole derivative, lansoprazole, and cytosine. Us, cytosine is selected as the secondary ligand for the formation of ternary complexes. Its chemical name is 4-amino-1Hpyrimidine-2 one [10]

Experimental

Result and Discussion

Conclusion