Spectra Characterization, In vitro Evaluation of Antibacterial and Hemolytic Activity of Novel Ligand 5-(5-{(2Z)-2-[(2-Hydroxynaphthalen-1- yl)Methylidene]Hydrazinyl}-1,3,4-Oxadiazol-2-yl)Benzene-1,2,3-Triol with some its Transition Metal Complexes

Abstract

A new series of transition metal (Cr(III), Co(II), Ni(II)and Cu(II) complexes of ligand 5-(5-{(2Z)-2-[(2- hydroxynaphthalen-1- yl)methylidene]hydrazinyl}-1,3,4-oxadiazol-2-yl)benzene-1,2,3-triol were synthesized and evaluated for its biological activities. A ligand was synthesized by reaction propyl gallate and hydrazine hydrate in presence of ethanol to give 3, 4, 5- trihydroxybenzohydrazide followed by reaction with potassium hydroxide and carbon disulfide, the resultant was mixed with hydrazine hydrate to produce the ligand. The newly synthesized compounds were characterized by Fourier transform infrared (FTIR)Spectroscopy, Nuclear Magnetic Resonance Spectroscopy (1H NMR), elemental analyses (C, H, N), mass spectral, conductivity measurement, and magnetic susceptibility data. The Hyperchem 7.51 program have been used to draw the ligand geometry optimization and then study the electrostatic potential that given right data about the active site. Antibacterial activity and hemolysis assay of prepared compounds were studied. Antibacterial activity was carried out against Escherichia coli, Salmonella, and Staphylococcus aureus with test compounds at four concentrations of (50,100,250,500μg/ml). Erythromycin was the standard drug utilize. Some of these compounds showed good efficacy, while others ranged from medium to small.