Synthesis, Characterization and Pharmacological evaluation of some Cinnoline derivatives

Abstract

The review of literature showed that cinnoline derivatives were found to elicit many pharmacological actions like anti-hypertensive, antithrombotic, antihistamine, antileukemic, CNS activity, anti tumor, antibacterial and antisecretory activity. Furan can be found in many other drugs such as dacarbazine, metronidazole, cimetidine, flumazenil, thyroliberin, methimazole, pilocarpine and etomidate which are used as antineoplastic antibiotic, antiulcerative, benzodiazepine antagonist, prohormone, antihyperthyroid, muscarinic receptor. In the substituted Cinnoline furan series, the compounds which are halogen mainly Chloro Substituted were showed potent antibacterial, anti-inflammatory and anti-fungal activity than other compounds. However Methyl substituted compound also Showed more potent antimicrobial activity and anti-inflammatory activity I. Introduction Cinnolines: Cinnoline is a pale yellow solid, m.p. 24-25°C and was first discovered by Von Richter in 1883. He also prepared a cinnoline derivative from 2-aminophenylpropionic acid via intramolecular cyclization of the diazonium salt. The review of literature showed that cinnoline derivatives were found to elicit many pharmacological actions like anti- hypertensive, antithrombotic, antihistamine, antileukemic, CNS activity, anti tumor, antibacterial and antisecretory activity. They are reactive by virtue of the presence of a benzene ring and the electrophillic attack takes place in this ring. Cinnolines are the six-membered heterocyclic compounds having two hetero atoms in the ring. They are also called as 1, 2- benzodiazine or benzopyridazine or 1, 2- diazanaphthalene or phenodiazine. (VI)