Structure-Activity Adverse Effect Relationship of Condensated As-Triazine Derivatives

Abstract

Several compounds of the condensated as. triazine group possess marked antiinflammatory or CNS activity or both. Results of an oral dose range finding study in rats with one of the most effective molecules, pointed to haematological alterations accompanied by splenomegaly. In long-term studies maximum spleen mass could be measured after two weeks, without any further change.Base on the above results groups of animals were treated for two-weeks either with derivatives showing antiinflammatory and/or CNS activity or with ineffective molecules of the as. triazine family. The greatest increase in spleen mass was observed after the administration of molecules having both CNS and antiinflammatory activity. The phenomenon was less marked after treatment with compounds possessing antiinflammatory action alone. In studies with CNS active or ineffective molecules, splenomegaly only occurred sporadically. The structure-adverse effect relationships point to the triazolo-benzo, and pirido-as-triazine derivatives, as the most potent compounds in this respect.Key wordsSplenomegalyStructure-activity-adverse effectRatsSubacute study